| References |
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Formal Name |
1,3,4,9,10,10aS-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-isopropyl-2H-9S,4aR-(epoxymethano)phenanthren-12-one |
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CAS Number |
5957-80-2 |
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Molecular Formula |
C20H26O4 |
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Formula Weight |
330.4 |
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Formulation |
A crystalline solid |
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Purity |
>96% |
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λmax |
212, 285 nm |
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Stability |
1 year |
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Storage |
-20°C |
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Shipping |
Wet ice in continental US; may vary elsewhere |
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SMILES |
CC(C)c1cc2C3OC(=O)C4(CCCC(C)(C)C4C3)c2c(O)c1O |
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Size |
Global Purchasing |
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1 mg |
|
|
5 mg |
|
|
10 mg |
|
|
50 mg |
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Description
arnosol is one of the phenolic antioxidants present in extracts of the herb rosemary (Rosmarinus officinalis). Carnosol inhibits the formation of tumors derived using irritants such as TPA and DMBA in murine models of carcinogenesis.1 The effective dose reported is 1-10 µM topically or 6 µg/ml when added to supernatants of cultured cells.2 Addition of rosemary extracts to the diet as a 1% supplement by weight was also found to decrease the frequency of DMBA-DNA adducts.1
1 Singletary, K., MacDonald, C., and Wallig, M. Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 104 43-48 (1996).
2 Chan, M.M., Ho, C.T., and Huang, H.I. Effects of three dietary phytochemicals from tea, rosemary, and turmeric on inflammation-induced nitrite production.. Cancer Lett 96 23-29 (1995).
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