| References |
| Synonyms |
- D-(+)-Catechin (hydrate)
- Cyanidol (hydrate)
- Catechuic Acid (hydrate)
|
| Formal Name |
2R-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3S,5,7-triol, hydrate |
| CAS Number |
225937-10-0 |
| Molecular Formula |
C15H14O6 · XH2O |
| Formula Weight |
290.3 |
| Formulation |
A crystalline solid |
| Purity |
>98% |
| λmax |
230, 280 nm |
| Stability |
2 years |
| Storage |
4°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| SMILES |
Oc1cc2OC(c3ccc(O)c(O)c3)[C@@H](O)Cc2c(O)c1
|
Background Reading
Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999).
Zhao, J., Wang, J., Chen, Y., et al. Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. Carcinogenesis 20 1737-1745 (1999).
Noreen, Y., Serrano, G., and Perera, P. Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalyzed prostaglandin biosynthesis. Planta Med 64 520-524 (1998).
| Size |
Global Purchasing |
| 1 g |
|
| 5 g |
|
| 10 g |
|
| 25 g |
|
Description
Catechin is a polyphenolic flavonoid which has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany. Catechin is a more potent antioxidant than ascorbate or α-tocopherol in certain in vitro assays of lipid peroxidation.1 Catechin inhibits the free radical-induced oxidation of isolated LDL by AAPH.2 It has also been reported to act as an inhibitor of COX-1 with an IC50 of about 80 µM.3 Catechin and other related procyanidin compounds have antitumor activity when tested in a two-stage mouse epidermal carcinoma model employing topical application.1
1
Zhao, J., Wang, J., Chen, Y., et al. Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. Carcinogenesis 20 1737-1745 (1999).
2
Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999).
3
Noreen, Y., Serrano, G., and Perera, P. Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalyzed prostaglandin biosynthesis. Planta Med 64 520-524 (1998).
|
