| References |
| Synonyms |
- 3,4-Dihydrocinnamic Acid (L-alanine methyl ester) amide
|
| Formal Name |
N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester |
| CAS Number |
778624-05-8 |
| Molecular Formula |
C13H15NO5 |
| Formula Weight |
265.3 |
| Formulation |
A crystalline solid |
| Purity |
>98% |
| λmax |
220, 242, 297, 325 nm |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| SMILES |
COC(=O)[C@H](C)NC(=O)\C=C/c1ccc(O)c(O)c1
|
Background Reading
Lee, S., Han, J., Kim, H., et al. Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA: Cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorg Med Chem Lett 14 4677-4681 (2004).
Lee, S., Lee, C., Oh, J., et al. Anti-atherogenic effects of 3,4-dihydroxy hydrocinnamides. Bioorg Med Chem Lett 13 2681-2682 (2003).
| Size |
Global Purchasing |
| 5 mg |
|
| 10 mg |
|
| 50 mg |
|
| 500 mg |
|
Description
The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting ACAT-1 or ACAT-2 activity.1,2 The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% CAY10487 in the diet was 16.1% compared to 53.5% in control rabbits.1 CAY10487 also exhibits antioxidant activity, inhibiting copper-mediated oxidation of low-density lipoprotein by about 75% at a concentration of 2 µM.2
1
Lee, S., Lee, C., Oh, J., et al. Anti-atherogenic effects of 3,4-dihydroxy hydrocinnamides. Bioorg Med Chem Lett 13 2681-2682 (2003).
2
Lee, S., Han, J., Kim, H., et al. Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA: Cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorg Med Chem Lett 14 4677-4681 (2004).
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