您的位置:首页>>Cayman>>Antioxidants>>CAY10512
Cat. Number
080786227749718
Chemical Name
CAY10512
References
Formal Name 1-​fluoro-​2-​[2-​(4-​methoxyphenyl)ethenyl]-​benzene
CAS Number 139141-12-1
Molecular Formula C15H13FO
Formula Weight 228.3
Formulation A crystalline solid
Purity >97%
λmax 229, 318 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES COc1ccc(cc1)​\C=C/c1ccccc1F

Background Reading

Heynekamp, J.J., Weber, W.M., Hunsaker, L.A., et al. Subsitituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor α-induced activation of transcription factor nuclear factor κB. J Med Chem 49 7182-7189 (2006).

Size Global Purchasing
10 mg  
50 mg  
100 mg  
500 mg  

Description

The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNF-α-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.1

1 Heynekamp, J.J., Weber, W.M., Hunsaker, L.A., et al. Subsitituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor α-induced activation of transcription factor nuclear factor κB. J Med Chem 49 7182-7189 (2006).

下一个:CAY10487上一个:CAY10616
在线咨询 联系方式 二维码

服务热线

021-60498804

扫一扫,关注我们