| References |
| Formal Name |
1-fluoro-2-[2-(4-methoxyphenyl)ethenyl]-benzene |
| CAS Number |
139141-12-1 |
| Molecular Formula |
C15H13FO |
| Formula Weight |
228.3 |
| Formulation |
A crystalline solid |
| Purity |
>97% |
| λmax |
229, 318 nm |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| SMILES |
COc1ccc(cc1)\C=C/c1ccccc1F
|
Background Reading
Heynekamp, J.J., Weber, W.M., Hunsaker, L.A., et al. Subsitituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor α-induced activation of transcription factor nuclear factor κB. J Med Chem 49 7182-7189 (2006).
| Size |
Global Purchasing |
| 10 mg |
|
| 50 mg |
|
| 100 mg |
|
| 500 mg |
|
Description
The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNF-α-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.1
1
Heynekamp, J.J., Weber, W.M., Hunsaker, L.A., et al. Subsitituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor α-induced activation of transcription factor nuclear factor κB. J Med Chem 49 7182-7189 (2006).
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