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| Cat. Number | 080749117950564 |
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| Chemical Name | Celastrol |
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| References |
Background ReadingJohnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998). Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol- Miller, N.J., and Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clin Chem 41 1789 (1995). Sassa, H., Takaishi, Y., and Terada, H. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem Biophys Res Commun 172(2) 890-897 (1990). Show all 4 Hide all but first 3
Description
A variety of natural products from plant sources, particularly flavonoids, have long been observed to have antioxidant activity with potential benefits for human health.1,2,3 Antioxidant triterpenes are less common. Celastrol is a triterpenoid antioxidant compound isolated from the Chinese Thunder of God vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC50 value of 7 µM, equivalent to about 15 times the antioxidant potency of α-
1
Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol- 2 Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998). 3 Miller, N.J., and Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clin Chem 41 1789 (1995). 4 Sassa, H., Takaishi, Y., and Terada, H. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem Biophys Res Commun 172(2) 890-897 (1990). |
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