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Cat. Number

080613212833999

Chemical Name

DL-α-Lipoic Acid

References

Synonyms	Thioctic acid
Formal Name	1,2-dithiolane-3-pentanoic acid
CAS Number	1077-28-7
Molecular Formula	C₈H₁₄O₂S₂
Formula Weight	206.3
Formulation	A crystalline solid
Purity	>95%
λ_max	203, 333 nm
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	OC(=O)CCCCC1SSCC1

Background Reading

Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29(3) 315-331 (1997).

Randle, P.J. Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14(4) 263-283 (1998).

Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The role of lipoic acid in the treatment of diabetic polyneuropathy*. Drug Metab Rev 29(4) 1025-1054 (1997).

Size	Global Purchasing
1 g
5 g
10 g
25 g

Description

DL-α-lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant.^1,2,3 DL-α-lipoic acid can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.

1 Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29(3) 315-331 (1997).

2 Randle, P.J. Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14(4) 263-283 (1998).

3 Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The role of lipoic acid in the treatment of diabetic polyneuropathy*. Drug Metab Rev 29(4) 1025-1054 (1997).

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