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Cat. Number

080573862753286

Chemical Name

Ellagic Acid

References

Synonyms	Lagistase TBBD Gallogen
Formal Name	2,3,7,8-tetrahydroxy-[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione
CAS Number	476-66-4
Molecular Formula	C₁₄H₆O₈
Formula Weight	302.2
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	OC1=C(O)C=C2C(C3=C4C=C(O)C(O)=C3OC2=O)=C1OC4=O

Size	Global Purchasing
100 mg
500 mg
1 g

Description

Ellagic acid is a polyphenolic antioxidant that is abundant in many fruits, vegetables, plant bark, and peels. It has anti-carcinogenic, anti-mutagenic, anti-inflammatory, and organ-preserving properties, presumably related to its ability to alter cytochrome P450 activity and improve metabolism and clearance of xenobiotics, as well as alter immune function.^1,2,3 Ellagic acid also blocks methylation of arginine 17 of histone 3 (H3R17) by coactivator-associated arginine methyltransferase 1 (CARM1) without significantly altering histone acetylase or DNA methyltransferase activity.^4,5,6

1 Allen, C.T., Peden-Adams, M.M., EuDaly, J., et al. Subchronic exposure to ellagic acid impairs cytotoxic T-cell function and suppresses humoral immunity in mice. Immunopharmacol Immunotoxicol 25(3) 409-422 (2003).

2 Heber, D. Multitargeted therapy of cancer by ellagitannins. Cancer Lett 269 262-268 (2008).

3 Girish, C., and Pradhan, S.C. Drug development for liver diseases: Focus on picroliv, ellagic acid and curcumin. Fundam Clin Pharmacol 22 623-632 (2008).

4 Selvi, B.R., Batta, K., Kishore, A.H., et al. Identification of a novel inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1)-mediated methylation of histone H3 Arg-17. J Biol Chem 285(10) 7143-7152 (2010).

5 Paluszczak, J., Krajka-Kuzniak, V., and Baer-Dubowska, W. The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells. Toxicol Lett 192(2) 119-125 (2010).

6 Lea, M.A., Ibeh, C., Han, L., et al. Inhibition of growth and induction of differentiation markers by polyphenolic molecules and histone deacetylase inhibitors in colon cancer cells. Anticancer Res 30(2) 311-318 (2010).

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