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Cat. Number

080550420138688

Chemical Name

EUK 118

References

Formal Name	(acetato-κO)[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[3,5-dimethoxyphenolato-κO]](2-)]-manganese
CAS Number	186299-34-3
Molecular Formula	C₂₂H₂₅MnN₂O₈
Formula Weight	500.4
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	COc1cc(OC)c2C=[N]3CC[N]4=Cc5c(OC)cc(OC)cc5[O-][Mn]34([Mn][Mn+])([O-]C(=O)C)[O-]c2c1

Background Reading

Walter, L., Franklin, A., Witting, A., et al. Nonpsychotropic cannabinoid receptors regulate microglial cell migration. J Neurosci 23(4) 1398-1405 (2003).

Size	Global Purchasing
5 mg
10 mg
50 mg
100 mg

Description

EUK 8 and EUK 134 are synthetic catalytic scavengers of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity.¹ EUK 118 is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. EUK 118 exhibits a catalase activity of 35 µM O₂ formed/minute from 10 mM hydrogen peroxide, which is more than four times lower that that observed for EUK 8 under the same conditions.² Superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity) was inhibited by EUK 118 and EUK 8 with IC₅₀ values of 2 and 0.7 µM, respectively. EUK 118 did not protect human dermal fibroblasts against hydrogen peroxide-induced cell death.²

1 Baker, K., Marcus, C.B., Huffman, K., et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther 284(1) 215-221 (1998).

2 Doctrow, S.R., Huffman, K., Marcus, C.B., et al. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: Structure-activity relationship studies. J Med Chem 45 4549-4558 (2002).

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