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Cat. Number

080532420246214

Chemical Name

EUK 124

References

Formal Name	chloro[[2,2’-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[3,5-dimethoxyphenolato-κO]](2-)]-manganese
CAS Number	186299-35-4
Molecular Formula	C₂₀H₂₂ClMnN₂O₆
Formula Weight	476.8
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	COc1cc(OC)c2C=[N]3CC[N]4=Cc5c(OC)cc(OC)cc5[O-][Mn]34([Cl-])([Mn][Mn+])[O-]c2c1

Background Reading

Doctrow, S.R., Huffman, K., Marcus, C.B., et al. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: Structure-activity relationship studies. J Med Chem 45 4549-4558 (2002).

Baker, K., Marcus, C.B., Huffman, K., et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther 284(1) 215-221 (1998).

Size	Global Purchasing
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Description

EUK 8 and EUK 134 are synthetic catalytic scavengers of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity.¹ EUK 124 is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. EUK 124 and EUK 8 inhibit superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity), with IC₅₀ values of 5 µM and 0.7 µM, respectively.²

1 Baker, K., Marcus, C.B., Huffman, K., et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther 284(1) 215-221 (1998).

2 Doctrow, S.R., Huffman, K., Marcus, C.B., et al. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: Structure-activity relationship studies. J Med Chem 45 4549-4558 (2002).

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