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Cat. Number

080454160798118

Chemical Name

Isoliquiritigenin

References

Synonyms	ISL GU 17
Formal Name	1-(2E,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
CAS Number	961-29-5
Molecular Formula	C₁₅H₁₂O₄
Formula Weight	256.3
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	OC1=CC=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(O)=C1

Size	Global Purchasing
1 mg
5 mg
10 mg
50 mg

Description

Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants that displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress.^1,2,3 ISL induces quinone reductase-1, a phase II enzyme that deactivates radicals and electrophiles, with a concentration required to double activity (CD) value of 1.8 μM in mouse hepatoma cells.²

1 Kim, D., Choi, S.S., Kim, S., et al. Isoliquiritigenin selectivity inhibits H2 histamine receptor signaling. Mol Pharmacol 70(2) 493-500 (2006).

2 Cuendet, M., Oteham, S.P., Moon, R.C., et al. Quinone Reductase Induction as a biomarker for cancer chemoprevention. J Nat Prod 69(3) 460-3 (2006).

3 Kim, Y.M., Kim, T.H., Kim, Y.W., et al. Inhibition of liver X receptor-α-dependent hepatic steatosis by isoliquiritigenin; a licorice antioxidant flavonoid, as mediated by JNK1 inhibition. Free Radic Biol Med 49 1722-34 (2010).

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