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Cat. Number
080433680566155
Chemical Name
MCI-186
References
Synonyms
  • NSC 2629
  • Edaravone
Formal Name 2,​4-​dihydro-​5-​methyl-​2-​phenyl-​3H-​pyrazol-​3-​one
CAS Number 89-25-8
Molecular Formula C10H10N2O
Formula Weight 174.2
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES O=C(CC(C)​=N1)​N1C2=CC=CC=C2

Background Reading

Xu, J., Shen, B., Li, Y., et al. Edaravone attenuates ischemia-reperfusion injury by inhibiting oxidative stress in a canine lung transplantation model. Chin Med J 121(16) 1583-1587 (2008).

Kikuchi, K., Kawahara, K., Tancharoen, S., et al. The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. J Pharmacol Exp Ther 329(3) 865-874 (2009).

Abe, K., Yuki, S., and Kogure, K. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 19 480-485 (1988).

Kono, H., Asakawa, M., Fujii, H., et al. Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J Pharmacol Exp Ther 307(1) 74-82 (2003).

Rajesh, K.G., Sasaguri, S., Suzuki, R., et al. Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. Am J Physiol Heart Circ Physiol 285 H2171-H2178 (2003).

Gao, Y., Ding, X., Xu, S., et al. Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage. Chin Med J 122(16) 1935-1940 (2009).

Show all 6 Hide all but first 3
Size Global Purchasing
500 mg  
1 g  
5 g  
10 g  

Description

MCI-186 is a free radical scavenger with diverse protective effects in vivo. Most notably, it reduces damage due to ischemia-reperfusion injury in lung, liver, and brain in animal models of transplant, infection, traumatic brain injury, and stroke.1,2,3,4 MCI-186 provides these protective effects, at least in part, by reducing reactive oxygen species, inhibiting apoptosis, and blocking nonenzymatic peroxidation and lipoxygenase activity.5,6,3

1 Xu, J., Shen, B., Li, Y., et al. Edaravone attenuates ischemia-reperfusion injury by inhibiting oxidative stress in a canine lung transplantation model. Chin Med J 121(16) 1583-1587 (2008).

2 Kono, H., Asakawa, M., Fujii, H., et al. Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J Pharmacol Exp Ther 307(1) 74-82 (2003).

3 Gao, Y., Ding, X., Xu, S., et al. Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage. Chin Med J 122(16) 1935-1940 (2009).

4 Kikuchi, K., Kawahara, K., Tancharoen, S., et al. The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. J Pharmacol Exp Ther 329(3) 865-874 (2009).

5 Rajesh, K.G., Sasaguri, S., Suzuki, R., et al. Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. Am J Physiol Heart Circ Physiol 285 H2171-H2178 (2003).

6 Abe, K., Yuki, S., and Kogure, K. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 19 480-485 (1988).

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