Rhapontigenin_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

服务热线：13917250134「同微信」

您的位置：首页>>Cayman>>Antioxidants>>Rhapontigenin

产品中心

/ Products Classification 点击展开+

Cat. Number

080367720285523

Chemical Name

Rhapontigenin

References

Formal Name	5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol
CAS Number	500-65-2
Molecular Formula	C₁₅H₁₄O₄
Formula Weight	258.3
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	COc1ccc(/C=C\c2cc(O)cc(O)c2)cc1O

Background Reading

Ohinata, Y., Payer, B., O'Carroll, D., et al. Blimp1 is a critical determinant of the germ cell lineage in mice. Nature 436 207-213 (2005).

Chun, Y.J., Ryu, S.Y., Jeong, T.C., et al. Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin. Drug Metab Dispos 29(4) 389-393 (2001).

Roberti, M., Pizzirani, D., Simoni, D., et al. Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. J Med Chem 46 3546-3554 (2003).

Roupe, K.A., Helms, G.L., Halls, S.C., et al. Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: Applications to metabolism, pharmacokinetics and anti-cancer studies. J Pharm Pharm Sci 8(3) 374-386 (2005).

Show all 4 Hide all but first 3

Size	Global Purchasing
1 mg
5 mg
10 mg
25 mg

Description

Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC₅₀ = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens.¹ At higher concentrations, rhapontigenin inhibits the proliferation of Hep-G₂ and HL-60R cancer cell lines (IC₅₀ = 48 μM).^2,3

1 Chun, Y.J., Ryu, S.Y., Jeong, T.C., et al. Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin. Drug Metab Dispos 29(4) 389-393 (2001).

2 Roupe, K.A., Helms, G.L., Halls, S.C., et al. Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: Applications to metabolism, pharmacokinetics and anti-cancer studies. J Pharm Pharm Sci 8(3) 374-386 (2005).

3 Roberti, M., Pizzirani, D., Simoni, D., et al. Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. J Med Chem 46 3546-3554 (2003).

下一个：Resveratrol-3-O-Sulfate上一个：Rosmarinic Acid

联系我们

电话：021-60498804
邮箱：info@e-biochem.com
地址：上海市徐汇区漕溪路258弄27号航星商务楼2-404

扫一扫，关注我们

惠诚品牌

产品中心: 分子生物; 分析化学; 生化试剂; 仪器耗材

企业动态

技术资料

在线咨询联系方式二维码

服务热线

021-60498804

扫一扫，关注我们