| References |
| Formal Name |
(2R)-[[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]methyl]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol, hydrochloride |
| CAS Number |
137018-55-4 |
| Molecular Formula |
C30H44N6O2 · 2HCl |
| Formula Weight |
593.6 |
| Formulation |
A crystalline solid |
| Purity |
≥98% |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| SMILES |
Cc1c(C)c2O[C@](C)(CCc2c(C)c1O)CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
|
Background Reading
Blasig, I.E., Mertsch, K., and Haseloff, R.F. Nitronyl nitroxides, a novel group of protective agents against oxidative stress in endothelial cells forming the blood-brain barrier. Neuropharmacology 43 1006-1014 (2002).
Sayyed, S.G., Kumar, A., and Sharma, S.S. Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathy. Life Sci 79 777-783 (2006).
Jacobsen, E.J., VanDoornik, F.J., Ayer, D.E., et al. 2-(aminomethyl) chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia. J Med Chem 35 4464-4472 (1992).
| Size |
Global Purchasing |
| 10 mg |
|
| 25 mg |
|
| 50 mg |
|
| 100 mg |
|
Description
U-83836E is an antioxidant which inhibits iron-dependent lipid peroxidation in rat brain with an IC50 value of 0.6 µM.1 This free radical scavenger has potent neuroprotective effects against ischemic injury and diabetic neuropathy.1,2 However at higher doses, U-83836E is highly cytotoxic. It reduces viability of rat brain endothelial cells (RBE4) with an IC50 value of 0.032 mM.3
1
Jacobsen, E.J., VanDoornik, F.J., Ayer, D.E., et al. 2-(aminomethyl) chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia. J Med Chem 35 4464-4472 (1992).
2
Sayyed, S.G., Kumar, A., and Sharma, S.S. Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathy. Life Sci 79 777-783 (2006).
3
Blasig, I.E., Mertsch, K., and Haseloff, R.F. Nitronyl nitroxides, a novel group of protective agents against oxidative stress in endothelial cells forming the blood-brain barrier. Neuropharmacology 43 1006-1014 (2002).
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