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Cat. Number

070598626200855

Chemical Name

GPR40 Polyclonal Antibody

References

Synonyms

Free Fatty Acid Receptor
FFAR1
G Protein-Coupled Receptor 40

Formulation

Peptide affinity-purified IgG

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human GPR40

Background Reading

Hardy, S., St-Onge, G.G., Joly, E., et al. Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40. J Biol Chem 280(14) 13285-13291 (2005).

Steneberg, P., Rubins, N., Bartoov-Shifman, R., et al. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab 1 245-258 (2005).

Yonezawa, T., Katoh, K., and Obara, Y. Existence of GPR40 functioning in a human breast cancer cell line, MCF-7. Biochem Biophys Res Commun 314 805-809 (2004).

Briscoe, C.P., Tadayyon, M., Andrews, J.L., et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem 278(13) 11303-11311 (2003).

Sawzdargo, M., George, S.R., Nguyen, T., et al. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. Biochem Biophys Res Commun 239 543-547 (1997).

Itoh, Y., Kawamata, Y., Harada, M., et al. Free fatty acids regulate insulin secretion from pancreatic b cells through GPR40. Nature 422 173-176 (2003).

Show all 6 Hide all but first 3

Size	Global Purchasing
500 µl

Description

Antigen: synthetic peptide from human GPR40 amino acids 210-222 · Host: rabbit · Application(s): IHC; other applications not tested · GPR40 is a seven transmembrane G Protein-coupled receptor with signalling mediated by medium- and long-chain fatty acids.^1,2 Found predominantly in the β-cells of pancreatic islets, it has been implicated in the regulation of insulin secretion.^3,4 Overexpression of GPR40 in mouse β cells leads to glucose intolerance suggesting a link between GPR40 expression and diabetes.^3,4 The receptor has also been identified as a possible mediator of oleate- and linoleate- stimulated proliferation of the human breast cancer cell line, MCF-7.^5,6 GPR40 has a calculated mass of 31.4 kDa bases on its amino acid sequence.

1 Sawzdargo, M., George, S.R., Nguyen, T., et al. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. Biochem Biophys Res Commun 239 543-547 (1997).

2 Itoh, Y., Kawamata, Y., Harada, M., et al. Free fatty acids regulate insulin secretion from pancreatic b cells through GPR40. Nature 422 173-176 (2003).

3 Briscoe, C.P., Peat, A.J., McKeown, S.C., et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: Identification of agonist and antagonist small molecules. Br J Pharmacol 148 619-628 (2006).

4 Yonezawa, T., Katoh, K., and Obara, Y. Existence of GPR40 functioning in a human breast cancer cell line, MCF-7. Biochem Biophys Res Commun 314 805-809 (2004).

5 Steneberg, P., Rubins, N., Bartoov-Shifman, R., et al. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab 1 245-258 (2005).

6 Hardy, S., St-Onge, G.G., Joly, E., et al. Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40. J Biol Chem 280(14) 13285-13291 (2005).

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