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Cat. Number

070575745483358

Chemical Name

GPx4 Polyclonal Antibody

References

Synonyms

Glutathione Peroxidase 4
PhGPx

Formulation

Peptide affinity-purified IgG

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Murine GPx4	+
Rat GPx4	+
Porcine GPx4	+

Background Reading

Giannattasio, A., Girotti, M., Williams, K., et al. Puberty influences expression of phospholipid hydroperoxide glutathione peroxidase (GPX4) in rat testis: Probable hypophysis regulation of the enzyme in male reproductive tract. J Endocrinol Invest 20 439-444 (1997).

Ursini, F., Heim, S., Kiess, M., et al. Dual function of the selenoprotein PHGPx during sperm maturation. Science 285 1393-1396 (1999).

Nakamura, T., Imai, H., Tsunashima, N., et al. Molecular cloning and functional expression of nucleolar phospholipid hydroperoxide glutathione peroxidase in mammalian cells. Biochem Biophys Res Commun 311 139-148 (2003).

Sun, Q., Kirnarsky, L., Sherman, S., et al. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Proc Natl Acad Sci USA 98(7) 3673-3678 (2001).

Pushpa-Rekha, T.R., Burdsall, A.L., Oleksa, L.M., et al. Rat phospholipid-hydroperoxide glutathione peroxidase. cDNA cloning and identification of multiple transcription and translation start sites. J Biol Chem 270(45) 26993-26999 (1995).

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Size	Global Purchasing
500 µl

Description

Antigen: human GPx4 amino acids 81-93 (TQLVDLHARYAEC) · Host: rabbit · Application(s): WB; other applications not tested · Phospholipid hydroperoxide glutathione peroxidase (GPx4 or PhGPx) is one of four characterized selenium-dependent glutathione peroxidases.¹ GPx4 is found primarily in the testis where it functions both to protect membrane phospholipids from oxidation in spermatids and as an insoluble structural protein in mature spermatozoa.^1,2 Three different post-translational forms of GPx4 have been characterized: mitochondrial, non-mitochondrial, and sperm nuclei specific selenoprotein (SnGPx).3 These monomeric GPx4 types migrate to 23, 20, and 34 kDa respectively.^2,3,4,5 GPx4 also forms a 69 kDa homotetramer.⁵ Cayman Chemical’s GPx4 polyclonal antibody can be used for western blot analysis of GPx4 on samples from murine, rat, and porcine, detecting both 20 kDa and 69 kDa bands. Sequence homology of the peptide antigen with that from other species indicates that the antibody is also expected to work on samples from human, bovine, canine, and chicken. Other applications for use of this antibody have not yet been tested.

1 Giannattasio, A., Girotti, M., Williams, K., et al. Puberty influences expression of phospholipid hydroperoxide glutathione peroxidase (GPX4) in rat testis: Probable hypophysis regulation of the enzyme in male reproductive tract. J Endocrinol Invest 20 439-444 (1997).

2 Ursini, F., Heim, S., Kiess, M., et al. Dual function of the selenoprotein PHGPx during sperm maturation. Science 285 1393-1396 (1999).

3 Nakamura, T., Imai, H., Tsunashima, N., et al. Molecular cloning and functional expression of nucleolar phospholipid hydroperoxide glutathione peroxidase in mammalian cells. Biochem Biophys Res Commun 311 139-148 (2003).

4 Sun, Q., Kirnarsky, L., Sherman, S., et al. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Proc Natl Acad Sci USA 98(7) 3673-3678 (2001).

5 Pushpa-Rekha, T.R., Burdsall, A.L., Oleksa, L.M., et al. Rat phospholipid-hydroperoxide glutathione peroxidase. cDNA cloning and identification of multiple transcription and translation start sites. J Biol Chem 270(45) 26993-26999 (1995).

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