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Cat. Number

070560545137749

Chemical Name

Guanylate Cyclase α subunit (soluble) Polyclonal Antibody

References

Synonyms

sGC α subunit

Formulation

500 µg affinity-purified IgG in 500 µl TBS, pH 7.4, containing 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human guanylate cyclase α subunit	+
Murine guanylate cyclase α subunit	+
Bovine guanylate cyclase α subunit	+

Background Reading

Stone, J.R., and Marletta, M.A. Soluble guanylate cyclase from bovine lung: Activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. Biochemistry 33 5636-5640 (1994).

Li, D., Zhou, N., and Johns, R.A. Soluble guanylate cyclase gene expression and localization in rat lung after exposure to hypoxia. Am J Physiol 277 841-847 (1999).

Nakane, M., Arai, K., Saheki, S., et al. Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung. J Biol Chem 265 16841-16845 (1990).

Nakane, M., Saheki, S., Kuno, T., et al. Molecular cloning of a cDNA coding for 70 kilodalton subunit of soluble guanylate cyclase from rat lung. Biochem Biophys Res Commun 157 1139-1147 (1988).

Koesling, D., Herz, J., Gausepohl, H., et al. The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase. FEBS Lett 239 29-34 (1988).

Koesling, D., Harteneck, C., Humbert, P., et al. The primary structure of the larger subunit of soluble guanylyl cyclase from bovine lung. Homology between the two subunits of the enzyme. FEBS Lett 266 128-132 (1990).

Giuili, G., Scholl, U., Bulle, F., et al. Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. FEBS Lett 304 83-88 (1992).

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Size	Global Purchasing
500 µl

Description

Antigen: human guanylate cyclase α subunit amino acids 418-436 (EQARAQDGLKKRLGKLKAT) · Host: rabbit · Application(s): WB · Soluble guanylate cyclase is a heterodimeric enzyme, composed of α and β subunits, that synthesizes cGMP from GTP. The enzyme is activated by the binding of nitric oxide or carbon monoxide to the heme group of the enzyme.¹ Chronic hypoxia upregulates soluble guanylate expression in rat lung.² The α1 subunit contains 690-717 amino acids and has a molecular mass of 77-82 kDa.^3,4,5 The cloned β1 subunit of guanylate cyclase from human, bovine, and rat sources contains 619 amino acids and has a molecular mass of approximately 70,000.^3,6,7

1 Stone, J.R., and Marletta, M.A. Soluble guanylate cyclase from bovine lung: Activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. Biochemistry 33 5636-5640 (1994).

2 Li, D., Zhou, N., and Johns, R.A. Soluble guanylate cyclase gene expression and localization in rat lung after exposure to hypoxia. Am J Physiol 277 841-847 (1999).

3 Giuili, G., Scholl, U., Bulle, F., et al. Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. FEBS Lett 304 83-88 (1992).

4 Nakane, M., Arai, K., Saheki, S., et al. Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung. J Biol Chem 265 16841-16845 (1990).

5 Lee, M., and Bell, R.M. Supplementation of the phosphatidyl-L-serine requirement of protein kinase C with nonactivating phospholipids. Biochemistry 31 5176-5182 (1992).

6 Koesling, D., Herz, J., Gausepohl, H., et al. The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase. FEBS Lett 239 29-34 (1988).

7 Nakane, M., Saheki, S., Kuno, T., et al. Molecular cloning of a cDNA coding for 70 kilodalton subunit of soluble guanylate cyclase from rat lung. Biochem Biophys Res Commun 157 1139-1147 (1988).

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