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Cat. Number

070483587320726

Chemical Name

HDAC6 Polyclonal Antibody

References

Synonyms

Histone Deacetylase 6

Formulation

100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human HDAC6	+
Murine HDAC6	+

Background Reading

Lin, H., Chen, C., Lin, S., et al. Targeting histone deacetylase in cancer therapy. Med Res Rev 26(4) 397-413 (2006).

Huang, L. Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. J Cell Physiol 39.1 611-616 (2006).

Cress, W.D., and Seto, E.J. Histone deacetylases, transcriptional control, and cancer. J Cell Physiol 184 1-16 (2000).

Meinke, P.T., and Liberator, P. Histone deacetylase: A target for antiproliferative and antiprotozoal agents. Curr Med Chem 8(2) 211-235 (2001).

Nakayama, T., and Takami, Y. Participation of histones and histone-modifying enzymes in cell functions through alterations in chromatin structure. J Biochem 129 491-499 (2001).

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Size	Global Purchasing
1 ea

Description

Antigen: synthetic peptide corresponding to amino acids 1-16 of human HDAC-6 · Host: rabbit · Isotype: IgG · Application(s): WB, IP, and ChIP · Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the ε-amino groups of lysines located near the amino termini of core histone proteins.¹ Eleven members of the HDAC family have been identified in the past several years.^2,3 These HDAC family members are divided into two classes, I and II. HDAC6 is a Class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrate. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation.^4,5 Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.⁴

1 Cress, W.D., and Seto, E.J. Histone deacetylases, transcriptional control, and cancer. J Cell Physiol 184 1-16 (2000).

2 Meinke, P.T., and Liberator, P. Histone deacetylase: A target for antiproliferative and antiprotozoal agents. Curr Med Chem 8(2) 211-235 (2001).

3 Nakayama, T., and Takami, Y. Participation of histones and histone-modifying enzymes in cell functions through alterations in chromatin structure. J Biochem 129 491-499 (2001).

4 Lin, H., Chen, C., Lin, S., et al. Targeting histone deacetylase in cancer therapy. Med Res Rev 26(4) 397-413 (2006).

5 Huang, L. Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. J Cell Physiol 39.1 611-616 (2006).

下一个：HDAC4 Polyclonal Antibody上一个：HDAC7 (Phospho-Ser155) Polyclonal Antibody

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