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Cat. Number
070350268241468
Chemical Name
Hsf2 Monoclonal Antibody (Clone 3E2)
References
Synonyms
  • Heat Shock Factor 2
Formula Weight 69.0
Formulation IgG at a concentration of 1 mg/ml in PBS, pH 7.4, containing 0.09% sodium azide and 50% glycerol
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human Hsf2 +
Murine Hsf2 +
Rat Hsf2 +
Guinea pig Hsf2 +
Hamster Hsf2 +
Monkey Hsf2 +
Rabbit Hsf2 +
Canine Hsf2 +
Bovine Hsf2 +
Ovine Hsf2 +
Porcine Hsf2 +
Show all 11 Hide all but first 3

Background Reading

Morano, K.A., and Thiele, D.J. Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals. Gene Expr 7 271-282 (1998).

Tanaka, K., Namba, T., Arai, Y., et al. Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis. J Biol Chem (2007).

McMillan, D.R., Xiao, X., Shao, L., et al. Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis. J Biol Chem 273(13) 7523-7528 (1998).

Fiorenza, M.T., Farkas, T., Dissing, M., et al. Complex expression of murine heat shock transcription factors. Nucleic Acids Res 23(3) 467-474 (1995).

Murphy, S.P., Gorzowski, J.J., Sarge, K.D., et al. Characterization of constitutive HSF2 DNA-binding activity in mouse embryonal carcinoma cells. Mol Cell Biol 14(8) 5309-5317 (1994).

Sarge, K.D., Park-Sarge, O., Kirby, J.D., et al. Expression of heat shock factor 2 in mouse testis: Potential role as a regulator of heat-shock protein gene expression during spermatogenesis. Biol Reprod 50 1334-1343 (1994).

Rallu, M., Loones, M., Lallemand, Y., et al. Function and regulation of heat shock factor 2 during mouse embryogenesis. Proc Natl Acad Sci USA 94 2392-2397 (1997).

Goodson, M.L., Park-Sarge, O., and Sarge, K.D. Tissue-dependent expression of heat shock factor 2 isoforms with distinct transcriptional activites. Mol Cell Biol 15(10) 5288-5293 (1995).

Jolly, C., Usson, Y., and Morimoto, R.I. Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules. Proc Natl Acad Sci USA 96 6769-6774 (1999).

Morimoto, R.I. Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev 12 3788-3796 (1998).

Show all 10 Hide all but first 3
Size Global Purchasing
25 µg  
100 µg  

Description

Antigen: purified mouse recombinant Hsf2 · Clone designation: 3E2 · Host: rat · Isotype: IgG1 · Application(s): WB · Heat shock factor 2 (Hsf2) belongs to a family of heat shock transcription factors that activate the transcription of genes encoding products required for protein folding, processing, targeting, degradation, and function.1 The up-regulation of heat shock protein (Hsp) expression by stressors is achieved at the level of transcription through a heat shock element (HSE) and a transcription factor.2,3,4 Most Hsfs have highly conserved amino acid sequences. On all Hsfs there is a DNA binding domain at the N-terminus. Hydrophobic repeats located adjacent to this binding domain are essential for the formation of active trimers. Towards the C-terminal region another short hydrophobic repeat exists and is thought to be necessary for suppression of trimerization.5 There are two main Hsfs, 1 and 2. Murine Hsf1 exists as two isoforms, however in higher eukaryotes Hsf1 is found in a diffuse cytoplasmic and nuclear distribution in unstressed cells. Once exposed to a multitude of stressors, it localizes to discrete nuclear granules within seconds. As it recovers from stress, Hsf1 dissipates from these granules to a diffuse nucleoplasmic distribution. Hsf2 on the other hand is similar to murine Hsf1, as it exists as two isoforms, the α form being more transcriptionally active than the smaller β form.6,7 Various experiments have suggested that Hsf2 may have roles in differentiation and development.8,9,10

1 Morano, K.A., and Thiele, D.J. Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals. Gene Expr 7 271-282 (1998).

2 Tanaka, K., Namba, T., Arai, Y., et al. Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis. J Biol Chem (2007).

3 Morimoto, R.I. Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev 12 3788-3796 (1998).

4 McMillan, D.R., Xiao, X., Shao, L., et al. Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis. J Biol Chem 273(13) 7523-7528 (1998).

5 Jolly, C., Usson, Y., and Morimoto, R.I. Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules. Proc Natl Acad Sci USA 96 6769-6774 (1999).

6 Fiorenza, M.T., Farkas, T., Dissing, M., et al. Complex expression of murine heat shock transcription factors. Nucleic Acids Res 23(3) 467-474 (1995).

7 Goodson, M.L., Park-Sarge, O., and Sarge, K.D. Tissue-dependent expression of heat shock factor 2 isoforms with distinct transcriptional activites. Mol Cell Biol 15(10) 5288-5293 (1995).

8 Rallu, M., Loones, M., Lallemand, Y., et al. Function and regulation of heat shock factor 2 during mouse embryogenesis. Proc Natl Acad Sci USA 94 2392-2397 (1997).

9 Sarge, K.D., Park-Sarge, O., Kirby, J.D., et al. Expression of heat shock factor 2 in mouse testis: Potential role as a regulator of heat-shock protein gene expression during spermatogenesis. Biol Reprod 50 1334-1343 (1994).

10 Murphy, S.P., Gorzowski, J.J., Sarge, K.D., et al. Characterization of constitutive HSF2 DNA-binding activity in mouse embryonal carcinoma cells. Mol Cell Biol 14(8) 5309-5317 (1994).

下一个：Hsf1 Monoclonal Antibody (Clone 10H8)上一个：Hsp25/Hsp27 Monoclonal Antibody (Clone 8A7)
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