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Cat. Number
070197687263960
Chemical Name
Interleukin-33 Monoclonal Antibody (Clone IL33026B)
References
Synonyms
  • NF-HEV
  • IL-33
  • IL-1F11
Formulation A 1 mg/ml solution in PBS, pH 7.4
Stability 6 months
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human IL-33 +
Mouse IL-33 +
Size Global Purchasing
50 µg  
100 µg  

Description

Antigen: recombinant human IL-33 · Clone designation: IL33026B · Host: mouse · Isotype: IgG1κ · Application(s): ELISA, IP, and WB · Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30 kDa human IL-33 is converted by CASP1 to a 18 kDa protein. IL-33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy and anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
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