| Synonyms |
|
| Formulation |
A 1 mg/ml solution in PBS, pH 7.4 |
| Stability |
6 months |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
|
| Size |
Global Purchasing |
| 50 µg |
|
| 100 µg |
|
Description
Antigen:
recombinant human IL-33
·
Clone designation:
IL333068A
·
Host:
mouse
·
Isotype:
IgG2bκ
·
Application(s):
ELISA and WB
·
Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30 kDa human IL-33 is converted by CASP1 to a 18 kDa protein. IL-33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy and anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
