| Synonyms |
- Interleukin-1 Receptor-Associated Kinase-Like 2
|
| Formulation |
100 µg of protein G-purfied IgG in 200 µl PBS containing 0.2% gelatin and 0.05% sodium azide |
| Stability |
6 months |
| Storage |
4°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
| Human IRAK-2 |
+ |
| Mouse IRAK-2 |
+ |
|
| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
synthetic peptide from human IRAK-2
·
Host:
rabbit
·
Application(s):
WB
·
The binding of interleukin-1 (IL-1) to its receptor IL-1RI initiates a signaling cascade that results in the activation of NF-κB. Protein kinases designated IL-1 receptor-associated kinases (IRAKs) have been identified and designated as IRAK-1-4. IRAK-2 is a serine/threonine protein kinase. The primary amino acid sequence of IRAK-2 shares similarity with that of Pelle, a protein kinase that is essential for the activation of the NF-κB homolog in Drosophila. IRAK mediates NF-κB activation by members of the IL-1 family including IL-1 and IL-18. Disruption of IRAK expression by anti-sense oligonucleotides inhibits IL-1- and IL-18-induced activation of NF-κB and activator protein, AP-1.
