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Cat. Number

070076760277349

Chemical Name

IκBα Polyclonal Antibody (aa 34-48)

References

Formulation

100 µg of protein G-purified IgG in 200 µl PBS, containing 0.2% gelatin and 0.05% sodium azide

Stability

6 months

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human IκBα

Size	Global Purchasing
1 ea

Description

Antigen: synthetic peptide corresponding to human IκBα amino acids 34-48 · Host: rabbit · Application(s): WB · Specific activity: amino acids 34-48 · NF-κB is silenced in the cytoplasm by an inhibitory protein IkB.¹ Synthesis of IκBα is autoregulated.² IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/γ.^3,4,5,6 External stimuli such as tumor necrosis factor or other cytokines induce phosphorylation and degradation of IκB releasing NF-κB dimers. NF-κB dimers subsequently translocate to the nucleus and activate target genes. Six members of the IkB family members have been identified.¹ One of the first genes induced following NF-κB activation is IκBα.

1 Verma, I.M., Stevenson, J.K., Schwarz, E.M., et al. Rel/NF-κB/IκB family: Intimate tales of association and dissociation. Genes Dev 9 2723-2735 (1995).

2 Verma, I.M., and Stevenson, J. IκB kinase: Beginning, not the end. Proc Natl Acad Sci USA 94 11758-11760 (1997).

3 DiDonato, J.A., Hayakawa, M., Rothwarf, D.M., et al. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388 548-554 (1997).

4 Régnier, C.H., Song, H.Y., Gao, X., et al. Identification and characterization of an IκB kinase. Cell 90 373-383 (1997).

5 Mercurio, F., Zhu, H., Murray, B.W., et al. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation. Science 278(5339) 860-866 (1997).

6 Yamaoka, S., Courtois, G., Bessia, C., et al. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell 93 1231-1240 (1998).

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