| Synonyms |
|
| Formulation |
100 µg of protein G-purified IgG in 200 µl PBS, containing 0.2% gelatin and 0.05% sodium azide. |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
|
| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
synthetic peptide corresponding to mouse IkBζ amino acids 684-699 and 285-298
·
Host:
rabbit
·
Application(s):
WB
·
Specific activity:
amino acids 684-699 and 285-298
·
IκBζ is an ankyrin repeat-containing nuclear protein that is highly homologous to the IκB family member Bcl-3. Transcription of IκBζ is upregulated by stimulation with TLR ligands, IL-1, and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkBz preferentially associates with the NF-κB subunit p50 rather than p65 and recombinant IκBζ proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
