| Synonyms |
- PTDSR
- Jumonji Domain Containing 6
|
| Formulation |
100 µg of antigen affinity-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium salt |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
| Chimpanzee JMJD6 |
+ |
| Ovine JMJD6 |
+ |
| Canine JMJD6 |
+ |
| Equine JMJD6 |
+ |
| Human JMJD6 |
+ |
| Murine JMJD6 |
+ |
| Opossum JMJD6 |
+ |
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|
| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
synthetic peptide corresponding to human PTDSR amino acids 127-144
·
Host:
Rabbit
·
Isotype:
Rabbit Ig
·
Application(s):
WB
·
JMJD6 is a 403 amino acid nuclear protein that acts as a bifunctional arginine demethylase and lysyl-hydroxylase. JMJD6 demethylates histone H3 at ‘Arg-2’ and histone H4 at ‘Arg-3’ and is known to function in the differentiation of multiple organs during embryogenesis, and regulate hematopoietic differentiation and macrophage cytokine responses. First identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells, JMJD6 was later indicated not to directly function in the clearance of apoptotic cells. It is ubiquitously expressed in most tissues and is upregulated in patients with chronic pancreatitis and upon cytokine treatment, but not upon TNF-α treatment.
