| Synonyms |
|
| Formulation |
100 µg peptide affinity-purified G in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide |
| Stability |
6 months |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
| Chicken MEK1/2 |
+ |
| Chimpanzee MEK1/2 |
+ |
| Ovine MEK1/2 |
+ |
| Canine MEK1/2 |
+ |
| Drosophila MEK1/2 |
+ |
| Human MEK1/2 |
+ |
| Murine MEK1/2 |
+ |
| Rat MEK1/2 |
+ |
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|
| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
synthetic peptide corresponding to a portion of human MEK1 amino acids 200-250
·
Host:
rabbit
·
Application(s):
WB
·
Peptide sequence:
amino acids 200-250
·
MEK1 and MEK2 are integral components of the MAP kinase (MAPK) cascade that regulates cell growth and differentiation and this pathway also plays a key role in synaptic plasticity in the brain. Activation of MEK1/2 occurs via phosphorylation of two serine residues (Ser218 and Ser222). Activated MEK1/2 then acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on ERK. This phosphorylation of ERK by MEK1/2 is a critical step in the MAPK cascade.
