| Synonyms |
- MAP Kinase/ERK Kinase Kinase 2
- Dual Specificity MAP Kinase Kinase Kinase 2
- MAP3K2
- MAPKKK2
|
| Formulation |
100 µg of protein G-purified IgG in 200 µl PBS containing 0.2% gelatin and 0.05% sodium azide |
| Stability |
6 months |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
|
| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
synthetic peptide within the region of human MEKK2 amino acids 1-50
·
Host:
rabbit
·
Application(s):
IHC (paraffin embedded-sections) and WB
·
Specific activity:
amino acids 1-50
·
MEKK2 is a serine/threonine protein kinase, belonging to the mitogen-activated protein kinase (MAPK) family. It plays an important role in activation of MAPK and preferentially activates other kinases involved in the MAPK signaling pathway. MEKK2 is known to directly phosphorylate and activate IκB kinases, and thus plays a role in the NF-κB signaling pathway. It regulates T-cell function, controls cytokine gene expression in mast cells, mediates epidermal growth factor receptors and fibroblast growth factor-2 receptor signals, and plays a role in rheumatoid arthritis. It is also involved in LPS-TLR4 signaling, due to its phosphorylation after TLR4 activation by LPS.
