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Cat. Number
069904798268191
Chemical Name
Metastasis Associated 1 Family Member 2 Polyclonal Antibody
References
Synonyms
  • p53 Target Protein in Deacetylase Complex
  • MTA2
  • MTA-L1 Protein
  • PID
Formulation 100 µg of antigen affinity-G-purified IgG in 200 µl PBS containing 0.2% geltain and 0.05% sodium azide
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Chimpanzee MTA2 +
Human MTA2 +
Rhesus monkey MTA2 +

Background Reading

Yao, Y., and Yang, W. The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. J Biol Chem 278(43) 42560-42568 (2003).

Luo, J., Su, F., Chen, D., et al. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408 377-381 (2000).

Size Global Purchasing
1 ea  

Description

Antigen: synthetic peptide from a portion of human MTA2 amino acids 650-700 · Host: Rabbit · Application(s): IHC and WB · Metastasis Associated 1 Family Member 2 (MTA2), a homologue of human MTA1 and MTA3, is a member of the highly conserved MTA gene family. It is a component of an ATP-dependent nucleosome remodeling (NuRD) and histone deacetylase complex. MTA2 is a nuclear protein that interacts with HDAC1 and HDAC2 and has a functional role in chromatin remodeling and deacetylase activity. MTA2 specifically interacts with p53 and represses p53-dependent transcriptional activation, thereby regulating p53-mediated cell growth arrest and apoptosis. It also inhibits the transcriptional activity of estrogen receptor-α. Northern blot analysis indicates a ubiquitous expression of MTA2.
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