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Cat. Number

069838844944727

Chemical Name

Monoacylglycerol Lipase (FL) Polyclonal Antibody

References

Synonyms

MAGL

Formulation

purified rabbit polyclonal IgG in 500 μl TBS, pH 7.4, containing 50% glycerol, 0.5 mg/mL BSA, and 0.02% sodium azide

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human MAGL	+
Rat MAGL	+

Background Reading

Dinh, T.P., Carpenter, D., Leslie, F.M., et al. Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc Natl Acad Sci USA 99(16) 10819-10824 (2002).

Karlsson, M., Reue, K., Xia, Y., et al. Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene. Gene 272 11-18 (2001).

Karlsson, M., Contreras, J.A., Hellman, U., et al. cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. J Biol Chem 272 27218-27223 (1997).

Dinh, T.P., Freund, T.F., and Piomelli, D. A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Chem Phys Lipids 121 149-158 (2002).

Chon, S., Zhou, Y.X., Dixon, J.L., et al. Intestinal monoacylglycerol metabolism developmental and nutritional regulation of monoacylglycerol lipase and monoacylglycerol acyltransferase. J Biol Chem 282(46) 33346-33357 (2007).

Vila, A., Rosengarth, A., Piomelli, D., et al. Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. Biochemistry 46 9578-9585 (2007).

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Size	Global Purchasing
500 µl

Description

Antigen: purified recombinant human monoacylglycerol lipase · Host: rabbit · Application(s): ICC, IHC, and WB · Endocannabinoids, such as arachidonoyl ethanolamide (AEA) and 2-arachidonoyl glycerol (2-AG), function as short-range modulators of cell and synaptic activity. Monoacylglycerol lipase (MAGL) hydrolyzes 2-AG to terminate its biological actions and works consecutively with hormone-sensitive lipase to mobilize fatty acids from the triglyceride stores of adipocytes.^1,2 MAGL has a molecular weight of ~33 kDa and exhibits a high degree of homology among human, murine, and rat at the amino acid level.^1,2,3,4 The enzyme is expressed in a variety of tissues with most abundant expression in skeletal muscle and adipose tissue, suggesting a role of MAGL in monoglyceride hydrolysis in diverse tissues. Cayman’s MAGL polyclonal antibody can be used for western blot, immunocytochemistry, and immunohistochemistry (paraffin embedded sections) analysis for MAGL.

1 Dinh, T.P., Carpenter, D., Leslie, F.M., et al. Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc Natl Acad Sci USA 99(16) 10819-10824 (2002).

2 Karlsson, M., Reue, K., Xia, Y., et al. Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene. Gene 272 11-18 (2001).

3 missing reference text

4 Dinh, T.P., Freund, T.F., and Piomelli, D. A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Chem Phys Lipids 121 149-158 (2002).

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