| Formulation |
100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
| Human NF-κB (p65) |
+ |
| Mouse NF-κB (p65) |
+ |
| Rat NF-κB (p65) |
+ |
|
| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
synthetic peptide corresponding to human NF-κB (p65) amino acids 526-539
·
Clone designation:
112A1021
·
Host:
mouse
·
Isotype:
IgG1κ
·
Application(s):
FC, IHC, and WB
·
NF-κB regulates the expression of a large number of genes that play critical roles in apoptosis, viral replication, tumorigenesis, various autoimmune diseases, and inflammation. The active nuclear form of the NF-κB transcription factor complex is composed of two DNA binding subunits, NF-κB p65 and p50, both of which share extensive N-terminal sequence homology with the v-rel oncogene product. N-terminal regions of p50 and p65 are critical for DNA binding and help determine the DNA-binding specificities of p50 and p65.
