Nod2 Monoclonal Antibody (Clone 2D9)_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

服务热线：13917250134「同微信」

您的位置：首页>>Cayman>>Antibodies>>Nod2 Monoclonal Antibody (Clone 2D9)

产品中心

/ Products Classification 点击展开+

Cat. Number

069629337918645

Chemical Name

Nod2 Monoclonal Antibody (Clone 2D9)

References

Formulation

200 µg protein-a purified IgG1.kappa. in 200 µl PBS, pH 7.4, containing 0.02% sodium azide

Stability

1 year

Storage

4°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human Nod2

Background Reading

Ogura, Y., Inohara, N., Benito, A., et al. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J Biol Chem 276 4812-4818 (2001).

Hugot, J., Chamaillard, M., Zouali, H., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 411 599-603 (2001).

Ogura, Y., Bonen, D.K., Inohara, N., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature 411 603-606 (2001).

Bertin, J., Nir, W., Fischer, C.M., et al. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB. J Biol Chem 274 12955-12958 (1999).

Inohara, N., Koseki, T., del Peso, L., et al. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB. J Biol Chem 274 14560-14567 (1999).

Inohara, N., Ogura, Y., Chen, F.F., et al. Human NOD1 confers responsiveness to bacterial lipopolysaccharides. J Biol Chem 276 2551-2554 (2001).

Inohara, N., Koseki, T., Lin, J., et al. An induced proximity model for NF-κB activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem 275 27823-27831 (2000).

Gutierrez, O., Pipaon, C., Inohara, N., et al. Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-κB activation. J Biol Chem 277(44) 41701-41705 (2002).

Ogura, Y., Lala, S., Xin, W., et al. Expression of NOD2 in Paneth cells: A possible link to Crohn’s ileitis. Gut 52 1591-1597 (2003).

Show all 9 Hide all but first 3

Size	Global Purchasing
1 ea

Description

Antigen: human recombinant Nod2 amino acids 28-301 · Clone designation: 2D9 · Host: mouse · Application(s): WB and IHC; other applications not tested · Nod2 is a member of the apoptosis regulating protein family that has caspase recruitment-domains (CARDs) and also includes Apaf-1 and Nod1.¹ Nod2 contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). Nod2 is expressed in monocytes whereas Nod1 (CARD4) is expressed in multiple tissues.^1,2,3,4 Both Nod1 and Nod2 act as intracellular receptors for bacterial lipopolysaccharides, activate NF-kB, and contribute to inflammatory bowel disease.^3,5,6,7 A frameshift mutation in the NOD2 gene is associated with susceptibility to Crohn’s disease, possibly by causing truncation of the tenth LRR.^8,9 Cayman Chemical’s NOD2 Monoclonal Antibody can be used for western blot and immunohistochemical analysis of Nod2 on samples of human origin. The antibody will also recognize three Nod2 polymorphisms: L1007finsC, G908R, and R702W.²

1 Ogura, Y., Inohara, N., Benito, A., et al. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J Biol Chem 276 4812-4818 (2001).

2 Ogura, Y., Lala, S., Xin, W., et al. Expression of NOD2 in Paneth cells: A possible link to Crohn’s ileitis. Gut 52 1591-1597 (2003).

3 Bertin, J., Nir, W., Fischer, C.M., et al. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB. J Biol Chem 274 12955-12958 (1999).

4 Gutierrez, O., Pipaon, C., Inohara, N., et al. Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-κB activation. J Biol Chem 277(44) 41701-41705 (2002).

5 Inohara, N., Koseki, T., del Peso, L., et al. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB. J Biol Chem 274 14560-14567 (1999).

6 Inohara, N., Ogura, Y., Chen, F.F., et al. Human NOD1 confers responsiveness to bacterial lipopolysaccharides. J Biol Chem 276 2551-2554 (2001).

7 Inohara, N., Koseki, T., Lin, J., et al. An induced proximity model for NF-κB activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem 275 27823-27831 (2000).

8 Ogura, Y., Bonen, D.K., Inohara, N., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature 411 603-606 (2001).

9 Hugot, J., Chamaillard, M., Zouali, H., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 411 599-603 (2001).

下一个：nNOS Polyclonal Antibody上一个：Normal Rabbit IgG-FITC

联系我们

电话：021-60498804
邮箱：info@e-biochem.com
地址：上海市徐汇区漕溪路258弄27号航星商务楼2-404

扫一扫，关注我们

惠诚品牌

产品中心: 分子生物; 分析化学; 生化试剂; 仪器耗材

企业动态

技术资料

在线咨询联系方式二维码

服务热线

021-60498804

扫一扫，关注我们