Optineurin (C-Term) Polyclonal Antibody_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

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Cat. Number

069621894214517

Chemical Name

Optineurin (C-Term) Polyclonal Antibody

References

Synonyms	NRP FIP-2
Formulation	Peptide affinity-purified IgG
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere

Background Reading

Wang, N., Chintala, S.K., Fini, M.E., et al. Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype. Nat Med 7 304-309 (2001).

Li, Y., Kang, J., and Horwitz, M.S. Interaction of an adenovirus E₃ 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains. Mol Cell Biol 18(3) 1601-1610 (1998).

Hattula, K., and Peränen, J. FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis. Curr Biol 10 1603-1606 (2000).

Kamphuis, W., and Schneeman, A. Optineurin gene expression level in human trabecular meshwork does not change in response to pressure elevation. Ophthalmic Res 35 93-96 (2003).

Vittitow, J.L., and Borrás, T. Expression of optineurin, a glaucoma-linked gene, is influenced by elevated intraocular pressure. Biochem Biophys Res Commun 298 67-74 (2002).

Schwamborn, K., Weil, R., Courtois, G., et al. Phorbol esters and cytokines regulate the expression of the NEMO-related protein, a molecule involved in a NF-κB-independent pathway. J Biol Chem 275(30) 22780-22789 (2000).

Rezaie, T., Child, A., Hitchings, R., et al. Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Science 295 1077-1079 (2002).

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Size	Global Purchasing
1 trial size Sufficient for 3 western blots
500 µl

Description

Antigen: human, murine, and rat (100% identity) optineurin amino acids 575-591 (GEVLPDIDTLQIHVMDC) · Host: rabbit · Application(s): WB; other applications not tested · Optineurin (originally named FIP-2) is a 74 kDa protein implicated in signal transduction of the tumor necrosis factor (TNF) pathway as well as membrane traffic regulation and cellular morphogenesis. Optineurin protein is also involved in apoptosis, although the exact role is currently unknown. Increased apoptosis of trabecular meshwork cells is a factor in the pathogenesis of glaucoma and mutations in the optineurin gene have been correlated with the some types of the disease. Cayman Chemical is a leading provider of prostaglandin analogs, such as latanoprost and fluprostenol, currently utilized for lowering the intraocular pressure (IOP) associated with glaucoma. Our optineurin polyclonal antibody is another research tool useful for delineating the physiology of the disease.

下一个：Normal Rabbit IgG-FITC上一个：Optineurin (INT) Polyclonal Antibody

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