p38 MAPK (Phospho-Thr180/Tyr182) Polyclonal Antibody_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

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Cat. Number

069608785668154

Chemical Name

p38 MAPK (Phospho-Thr180/Tyr182) Polyclonal Antibody

References

Synonyms

Anti-Phospho-Thr180/Tyr182 p38 MAPK

Formulation

Affinity-purified IgG

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human p38 MAPK

Background Reading

Johnson, G.L., and Lapadat, R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298 1911-1912 (2002).

Ying, S., Futter, M., Rosenblum, K., et al. Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: Requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22(5) 1532-1540 (2002).

Lin, A., Minden, A., Martinetto, H., et al. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268 286-290 (1995).

Philip, S., and Armstead, W.M. Differential role of PTK, ERK, and p38 MAPK in superoxide impairment of NMDA cerebrovasodilation.. Brain Res 979 98-103 (2003).

Shi, Y., and Gaestel, M. In the cellular garden of forking paths: How p38 MAPKs signal for downstream assistance.. Biol Chem 383 1519-1536 (2002).

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Size	Global Purchasing
1 ea

Description

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Thr¹⁸⁰ and phospho-Tyr¹⁸² of rat p38 MAPK · Host: rabbit · Application(s): WB · The three mitogen-activated protein kinases (MAPKs) are evolutionarily conserved protein kinases that control a vast array of cellular processes. p38 MAPK is one of these kinases and it is activated by both inflammatory cytokines and by stress.^1,2 The p38 MAPK is thought to be particularly important in diseases like asthma and autoimmunity but it also plays important roles in the stress response of the nervous system.^3,4 Like the other MAPKs, p38 is activated by a dual specificity kinase that phosphorylates Thr¹⁸⁰ and Tyr¹⁸².⁵

1 Johnson, G.L., and Lapadat, R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298 1911-1912 (2002).

2 Shi, Y., and Gaestel, M. In the cellular garden of forking paths: How p38 MAPKs signal for downstream assistance.. Biol Chem 383 1519-1536 (2002).

3 Ying, S., Futter, M., Rosenblum, K., et al. Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: Requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22(5) 1532-1540 (2002).

4 Philip, S., and Armstead, W.M. Differential role of PTK, ERK, and p38 MAPK in superoxide impairment of NMDA cerebrovasodilation.. Brain Res 979 98-103 (2003).

5 Lin, A., Minden, A., Martinetto, H., et al. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268 286-290 (1995).

下一个：p38 MAPK Monoclonal Antibody (Clone 9F12)上一个：p53 Monoclonal Antibody (Clone BP53-12)

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