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Cat. Number

069597249704472

Chemical Name

p66α Polyclonal Antibody

References

Synonyms

Transcriptional Repressor p66α
GATA Zinc Finger Domain-Containing Protein 2A

Formulation

IgG in 200 µl PBS containing 0.05% sodium azid

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human p66α	+
Murine p66α	+
Rat p66α	+

Background Reading

Tong, J.K., Hassig, C.A., Schnitzler, G.R., et al. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature 395 917-921 (1998).

Xue, Y., Wong, J., Moreno, G.T., et al. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell 2(6) 851-861 (1998).

Feng, Q., Cao, R., Xia, L., et al. Identification and functional characterization of the p66/p68 components of the MeCP1 complex. Mol Cell Biol 22(2) 536-546 (2002).

Zhang, Y., Ng, H., Erdjument-Bromage, H., et al. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev 13 1924-1935 (1999).

Show all 4 Hide all but first 3

Size	Global Purchasing
1 ea

Description

Antigen: synthetic peptide corresponding mouse p66α amino acids 575-585 · Host: Rabbit · Application(s): WB · Methylation of cytosine at CpG dinucleotides is a common feature of many higher eukaryotic genomes.^1,2,3 Increasing evidence indicates that recruitment of histone deacetylase complexes by methyl-CpG-binding proteins (MeCP) is a major mechanism of methylated DNA silencing. p66, a zinc finger-containing protein, is one of the components of the MeCP1 complex.⁴ p66 and p68, the two components of MeCP1, are different forms of the same zinc finger-containing protein and are conserved from C. elegans to humans. Homologs of p66 from different organisms revealed two highly conserved regions, CR1 and CR2. While CR1 is involved in the association of p66 with other MeCP1 components, CR2 plays an important role in targeting p66 and MBD3 to specific loci.⁴

1 Feng, Q., Cao, R., Xia, L., et al. Identification and functional characterization of the p66/p68 components of the MeCP1 complex. Mol Cell Biol 22(2) 536-546 (2002).

2 Tong, J.K., Hassig, C.A., Schnitzler, G.R., et al. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature 395 917-921 (1998).

3 Xue, Y., Wong, J., Moreno, G.T., et al. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell 2(6) 851-861 (1998).

4 Zhang, Y., Ng, H., Erdjument-Bromage, H., et al. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev 13 1924-1935 (1999).

下一个：p53 (Phospho-Ser392) Polyclonal Antibody上一个：PAF Acetylhydrolase (human) Polyclonal Antibody

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