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Cat. Number
069591936389644
Chemical Name
PAF Receptor (human) Monoclonal Antibody (11A4, Clone 21)
References
Synonyms
  • Platelet-activating Factor Receptor
Formulation Protein-A purified IgG2a
Stability 18 months
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Quellet, S., Müller, E., and Rola-Pleszczynski, M. IFN-γ up-regulates platelet-activating factor receptor gene expression in human monocytes. J Immunol 152 5092-5099 (1994).

Nakamura, M., Honda, Z., Izumi, T., et al. Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. J Biol Chem 266(30) 20400-20405 (1991).

Ye, R.D., Prossnitz, E.R., Zou, A., et al. Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. Biochem Biophys Res Commun 180 105-111 (1991).

Honda, Z., Nakamura, M., Miki, I., et al. Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Nature 349 342-346 (1991).

Kunz, D., Gerard, N.P., and Gerard, C. The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog. J Biol Chem 267 9101-9106 (1992).

Bito, H., Honda, Z., Nakamura, M., et al. Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA. Eur J Biochem 227 211-218 (1994).

Müller, E., Dagenais, P., Alami, N., et al. Identification and functional characterization of platelet-activating factor receptors in human leukocyte populations using polyclonal anti-peptide antibody. Proc Natl Acad Sci USA 90 5818-5822 (1993).

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Size Global Purchasing
1 ea  

Description

Antigen: human PAF amino acids 260-269 (LGFQDSKFHQ) · Clone designation: 11A4 (clone 21) · Host: mouse · Application(s): FC, ICC; may not work for western blot · IgG2a · PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling.1,2,3,4,5 Northern blot analysis reveals that the receptor is expressed in leukocytes, placenta, lung, spleen, small intestine, kidney, liver, and brain.3,4 In leukocyte cell populations the receptor is found on platelets, myocytes, neutrophils, and B-cells, whereas resting T-cells and natural killer cell lines do not express the PAF receptor.6 Human monocytes treated with INF-γ have a 2-6 fold increase in PAF receptor expression compared to untreated cells.7

1 Nakamura, M., Honda, Z., Izumi, T., et al. Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. J Biol Chem 266(30) 20400-20405 (1991).

2 Kunz, D., Gerard, N.P., and Gerard, C. The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog. J Biol Chem 267 9101-9106 (1992).

3 Ye, R.D., Prossnitz, E.R., Zou, A., et al. Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. Biochem Biophys Res Commun 180 105-111 (1991).

4 Bito, H., Honda, Z., Nakamura, M., et al. Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA. Eur J Biochem 227 211-218 (1994).

5 Honda, Z., Nakamura, M., Miki, I., et al. Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Nature 349 342-346 (1991).

6 Müller, E., Dagenais, P., Alami, N., et al. Identification and functional characterization of platelet-activating factor receptors in human leukocyte populations using polyclonal anti-peptide antibody. Proc Natl Acad Sci USA 90 5818-5822 (1993).

7 Quellet, S., Müller, E., and Rola-Pleszczynski, M. IFN-γ up-regulates platelet-activating factor receptor gene expression in human monocytes. J Immunol 152 5092-5099 (1994).

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