Phosphothreonine (Ascites) Monoclonal Antibody (Clone 18F6)_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

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Cat. Number

069523458554353

Chemical Name

Phosphothreonine (Ascites) Monoclonal Antibody (Clone 18F6)

References

Formulation	Antibody from clarified ascites containing 0.1% sodium azide
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere

Background Reading

Pawson, T., and Saxton, T.M. Signaling networks - Do all roads lead to the same genes? Cell 97 675-678 (1999).

Downward, J. The ins and outs of signalling. Nature 411 759-762 (2001).

Blume-Jensen, P., and Hunter, T. Oncogenic kinase signalling. Nature 411 355-365 (2001).

Goto, H., Kiyono, T., Tomono, Y., et al. Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. Nat Cell Biol 8 180-187 (2005).

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Size	Global Purchasing
100 µL

Description

Clone designation: 18F6 · Host: Mouse · Isotype: IgG1κ · Application(s): ELISA, WB · Protein phosphorylation is an important post-translational modification that serves many key functions to regulate a protein’s activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine; others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time.¹ Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation, and neurological disorders.^2,3,4

1 Goto, H., Kiyono, T., Tomono, Y., et al. Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. Nat Cell Biol 8 180-187 (2005).

2 Blume-Jensen, P., and Hunter, T. Oncogenic kinase signalling. Nature 411 355-365 (2001).

3 Downward, J. The ins and outs of signalling. Nature 411 759-762 (2001).

4 Pawson, T., and Saxton, T.M. Signaling networks - Do all roads lead to the same genes? Cell 97 675-678 (1999).

下一个：PH Domain Leucine-rich Repeat Protein Phosphatase 1 Polyclonal Antibody上一个：Phosphotyrosine (Ascites) Monoclonal Antibody (Clone 13F9)

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