| Synonyms |
- Protein Arginine Methyltransferase 6
|
| Formulation |
protein G-purified IgG in 200 µl of PBS containing 0.05% BSA and 0.05% sodium azide |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
| Human PRMT6 |
+ |
| Murine PRMT6 |
+ |
|
| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
synthetic peptide from human PRMT6 amino acids 23-43
·
Host:
rabbit
·
Application(s):
WB
·
Protein arginine methylation is an important post-translational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT6 was identified by searching the human genome for protein arginine methyltransferase (PRMT) family members. PRMT6 is a protein with an approximate molecular weight of 42 kDa consisting of a catalytic core sequence common to other PRMT enzymes. PRMT6 demonstrates type 1 PRMT activity, capable of forming both NG-monomethylarginine and asymmetric NG,NG-dimethylarginine derivatives on recombinant glycine- and arginine-rich substrates. A comparison of substrate specificity reveals that PRMT6 is functionally distinct from two previously characterized type 1 enzymes, PRMT1 and PRMT4. In addition to methylating substrate proteins, PRMT6 displays automethylation activity. GFP-fusion protein expression in the transfected cell lines suggest that PRMT6 localizes in the nucleus.
