Synonyms |
- Protein Arginine Methyltransferase 7
|
Formulation |
100 µg of protein G-purified IgG in 200 µl PBS containing 0.2% gelatin and 0.05% sodium azide |
Stability |
1 year |
Storage |
-20°C |
Shipping |
Wet ice
in continental US; may vary elsewhere
|
Specificity |
Human PRMT7 |
+ |
Murine PRMT7 |
+ |
|
Size |
Global Purchasing |
1 ea |
|
Description
Antigen:
synthetic peptide from human PRMT7 amino acid sequence 346-360
·
Host:
rabbit
·
Application(s):
WB
·
Protein arginine methylation (PRMT) is an important post-translational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. The PRMT proteins are recruited by C-terminal acitvation domain-2 of the steroid receptor coactivator (SRC) GRIP-1, whereas p300 interacts with activation domain-1 in the C-terminus. Researchers have identified a mammalian arginine N-methyltransferase, PRMT7, that can catalyze the formation of w-NG-monomethylarginine in peptides. In contrast to other members of the PRMT family, PRMT7 was not able to methylate GST-fibrillarin or myelin basic protein or histone H2A, in vitro. It is also structurally different from other PRMTs in containing two putative AdoMet-binding motifs. Both of these domains are required for enzymatic activity.