| References |
| Synonyms |
- mPGES-1
- mPGE Synthase-1
- Prostaglandin H/E Isomerase
- PIG12
- Membrane-Associated PGES-1
- MGST1-L1
|
| Formulation |
Peptide affinity-purified IgG |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
| Human mPGES |
+ |
| Mouse mPGES |
+ |
| Ovine mPGES |
+ |
| Rat mPGES |
+ |
| cPGES |
- |
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|
Background Reading
Arvind, P., Papavassiliou, E.D., Tsioulias, G.J., et al. Prostaglandin E2 down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines. Biochemistry 34 5604-5609 (1995).
Jackson, G.M., Sharp, H.T., and Varner, M.W. Cervical ripening before induction of labor: A randomized trial of prostaglandin E2 gel versus low-dose oxytocin. Am J Obstet Gynecol 171 1092-1096 (1994).
Willis, A.L., and Cornelsen, M. Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain threshold. Prostaglandins 3 353-357 (1973).
Guan, Y., Zhang, Y., Schneider, A., et al. Urogenital distribution of a mouse membrane-associated prostaglandin E2 synthase. Am J Physiol Renal Physiol 281 F1173-F1177 (2001).
Robert, A., Schultz, J.R., Nezamis, J.E., et al. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16,16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology 70 359-370 (1976).
Jakobsson, P., Thorén, S., Morgenstern, R., et al. Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA 96 7220-7225 (1999).
Mancini, J.A., Blood, K., Guay, J., et al. Cloning, expression, and up-regulation of inducible rat prostaglandin E synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis. J Biol Chem 276 4469-4475 (2001).
Yamagata, K., Matsumura, K., Inoue, W., et al. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J Neurosci 21(8) 2669-2677 (2001).
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| Size |
Global Purchasing |
| Trial Sufficient for 3 western blots |
|
| 500 µl |
|
Description
Antigen:
human mPGE synthase amino acids 59-75 (CRSDPDVERSLRAHRND)
·
Host:
rabbit
·
Application(s):
WB and IHC; other applications not tested
·
Prostaglandin E Synthase-1 (PGES-1) catalyzes the isomerization of PGH2 to PGE2. PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.1,2,3,4 PGES-1 is a 16 kDa membrane-associated protein with glutathione-dependent activity.5 The mRNA is for PGES-1 is expressed in a variety of tissues including prostate, testes, and small intestine, as well as in A549 and HeLa cells.5 PGES-1 protein expression is increased in A549 cells following treatment with IL-1β5
1
Willis, A.L., and Cornelsen, M. Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain threshold. Prostaglandins 3 353-357 (1973).
2
Jackson, G.M., Sharp, H.T., and Varner, M.W. Cervical ripening before induction of labor: A randomized trial of prostaglandin E2 gel versus low-dose oxytocin. Am J Obstet Gynecol 171 1092-1096 (1994).
3
Robert, A., Schultz, J.R., Nezamis, J.E., et al. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16,16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology 70 359-370 (1976).
4
Arvind, P., Papavassiliou, E.D., Tsioulias, G.J., et al. Prostaglandin E2 down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines. Biochemistry 34 5604-5609 (1995).
5
Jakobsson, P., Thorén, S., Morgenstern, R., et al. Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA 96 7220-7225 (1999).
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