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Cat. Number
069269265376664
Chemical Name
Prostaglandin E Synthase-2 (microsomal) Blocking Peptide
References
Synonyms
  • mPGES-2
  • Prostaglandin H/E Isomerase-2
  • PGES-2
  • PGE Synthase-2
  • Membrane-Associated PGES-2
Formulation 200 µg of peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Robert, A., Schultz, J.R., Nezamis, J.E., et al. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16,16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology 70 359-370 (1976).

Arvind, P., Papavassiliou, E.D., Tsioulias, G.J., et al. Prostaglandin E2 down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines. Biochemistry 34 5604-5609 (1995).

Jackson, G.M., Sharp, H.T., and Varner, M.W. Cervical ripening before induction of labor: A randomized trial of prostaglandin E2 gel versus low-dose oxytocin. Am J Obstet Gynecol 171 1092-1096 (1994).

Tanikawa, N., Ohmiya, Y., Ohkubo, H., et al. Identification and characterization of a novel type of membrane-associated prostaglandin E synthase. Biochem Biophys Res Commun 291(4) 884-889 (2002).

Watanabe, K., Kurihara, K., and Suzuki, T. Purification and characterization of membrane-bound prostaglandin E synthase from bovine heart. Biochim Biophys Acta 1439 406-414 (1999).

Engblom, D., Ek, M., Saha, S., et al. Prostaglandins as inflammatory messengers across the blood-brain barrier. J Mol Med 80 5-15 (2002).

Willis, A.L., and Cornelsen, M. Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain threshold. Prostaglandins 3 353-357 (1973).

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Size Global Purchasing
1 ea  

Description

Peptide sequence: amino acids 221-235 (VYGGKEARTEEMKWR) · To be used in conjunction with Cayman’s mPGE synthase-2 polyclonal antibody (Catalog No. 160145) to block protein-antibody complex formation during analysis for microsomal PGE synthase-2.
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