| Synonyms |
- RAR-Related Orphan Receptor
- ROR-γ
- NR1F3
|
| Formulation |
100 µg peptide affinity-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide |
| Stability |
6 months |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
| Chimpanzee ROR-γ |
(+) |
| Human ROR-γ |
(+) |
| Mouse ROR-γ |
(+) |
|
| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
A peptide within the region of amino acids 1-50 of human ROR-γ
·
Clone designation:
4G419
·
Host:
mouse
·
Isotype:
mouse IgG1,κ
·
Application(s):
FC and WB
·
ROR-γ is a 560 amino acid DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. The specific functions of this protein are not known. However, reports suggest that this protein is a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer’s patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR-γ inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR-γ shares 50 to 51% sequence identity with RORα and RORβ and is 88% identical to mouse ROR-γ. It is highly expressed in skeletal muscle and at lower levels in various other tissues.
