| References |
| Synonyms |
|
| Formulation |
Peptide affinity-purified antibody |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
| Rat RSK2 |
+ |
| Bovine RSK2 (expected) |
+ |
| Canine RSK2 (expected) |
+ |
| Chicken RSK2 (expected) |
+ |
| Murine RSK2 (expected) |
+ |
| Human RSK2 (expected) |
+ |
Show all 6
Hide all but first 3
|
Background Reading
Hanauer, A., and Young, I.D. Coffin-Lowry syndrome: Clinical and molecular features. J Med Genet 39 705-713 (2002).
Sheffler, D.J., Kroeze, W.K., Garcia, B.G., et al. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proc Natl Acad Sci USA 103 4717-4722 (2006).
| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
peptide corresponding to amino acid residues from the C-terminal region of rat RSK2
·
Host:
rabbit
·
Application(s):
WB
·
The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. The loss of RSK2 activity in humans leads to Coffin-Lowry syndrome, which is characterized by mental retardation and growth deficits.1 Recent work suggests that RSK2 exerts a tonic regulation on G protein-coupled signalling.2
1
Hanauer, A., and Young, I.D. Coffin-Lowry syndrome: Clinical and molecular features. J Med Genet 39 705-713 (2002).
2
Sheffler, D.J., Kroeze, W.K., Garcia, B.G., et al. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proc Natl Acad Sci USA 103 4717-4722 (2006).
|
