| Synonyms |
- Sphingosine-1-phosphate Receptor 2
- S1PR2
- EDG-5
|
| Formulation |
100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
| Human S1P2 |
+ |
| Monkey S1P2 |
+ |
| Murine S1P2 |
+ |
| Rat S1P2 |
+ |
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|
| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
synthetic peptide from human S1P2 amino acids 325-343
·
Host:
rabbit
·
Application(s):
WB
·
S1P2 is a membrane protein belonging to the EDG family of extracellular G protein-coupled receptors. It acts as a receptor for the bioactive lipid sphingosine 1-phosphate (S1P) and participates in S1P-induced cell proliferation, survival, and transcriptional activation. It shares 92% amino acid identity with rat H218 and approximately 44% identity with the human S1P receptors EDG-1 and EDG-3. Though the role of S1P2 in vascular permeability is not clear, reports suggest that it regulates PTEN by a Rho GTPase-dependent pathway to inhibit cell migration. S1P2 also plays an important role in normal vascularization and hypoxia-triggered pathological angiogenesis of the murine retina. The gene for human S1P2 protein is localized on chromosomal region 19p13.2. The protein is usually expressed in human brain and heart.
