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Cat. Number
069064200228699
Chemical Name
Serine Palmitoyltransferase Polyclonal Antibody
References
Synonyms
  • Serine-palmitoyl-CoA transferase, long chain base subunit 2
  • SPT
Formulation Peptide affinity-purified IgG
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human serine palmitoyltransferase +
Murine serine palmitoyltransferase +
Rat serine palmitoyltransferase +
Ovine serine palmitoyltransferase +
Porcine serine palmitoyltransferase +
Bovine serine palmitoyltransferase +
African green monkey serine palmitoyltransferase +
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Background Reading

Batheja, A.D., Uhlinger, D.J., Carton, J.M., et al. Characterization of serine palmitoyltransferase in normal human tissues. J Histochem Cytochem 51(5) 687-696 (2003).

Hanada, K., Hara, T., and Nishijima, M. Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques. J Biol Chem 275(12) 8409-8415 (2000).

Carton, J.M., Uhlinger, D.J., Batheja, A.D., et al. Enhanced serine palmitoyltransferase expression in proliferating fiboblasts, transformed cell lines, and human tumors. J Histochem Cytochem 51(6) 715-726 (2003).

Mathias, S., Peña, L.A., and Kolesnick, R.N. Signal transduction of stress via ceramide. Biochem J 335 465-480 (1998).

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Size Global Purchasing
500 µl  

Description

Antigen: human serine palmitoyltransferase subunit SPT2 amino acids 548-562 · Host: rabbit · Application(s): WB and IHC (formalin-fixed paraffin-embedded sections); other applications not tested · Sphingolipids play essential roles in various cellular events, including proliferation, differentiation, senescence, apoptosis, and inflammatory responses.1 Serine palmitoyltransferase (SPT) is the initial and rate-limiting enzyme in the de novo sphingolipid biosynthesis, and thus regulates the level of sphingolipids in cells.2 Immunohistochemical study revealed widespread distribution of the enzyme with most strong expression in brain and digestive tract.3 Two subunits, SPT1 and SPT2 at a stoichiometry of 1:1, are involved in the enzymatic activity of SPT.4 Cayman Chemical’s serine palmitoyltransferase polyclonal antibody recognizes SPT2, the long chain subunit of the enzyme. The antibody stains mainly cell nuclei and occasionally both cell nuclei and cytoplasm in formalin-fixed, paraffin-embedded rat brain tissue. The nuclear localization of SPT2 may suggest that SPT2 associates with another nuclear protein or is modified and transported to the nucleus.2

1 Mathias, S., Peña, L.A., and Kolesnick, R.N. Signal transduction of stress via ceramide. Biochem J 335 465-480 (1998).

2 Carton, J.M., Uhlinger, D.J., Batheja, A.D., et al. Enhanced serine palmitoyltransferase expression in proliferating fiboblasts, transformed cell lines, and human tumors. J Histochem Cytochem 51(6) 715-726 (2003).

3 Batheja, A.D., Uhlinger, D.J., Carton, J.M., et al. Characterization of serine palmitoyltransferase in normal human tissues. J Histochem Cytochem 51(5) 687-696 (2003).

4 Hanada, K., Hara, T., and Nishijima, M. Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques. J Biol Chem 275(12) 8409-8415 (2000).

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