| Synonyms |
- Silent Information Regulator 7
- Sirtuin 7
- Sir2
|
| Formulation |
100 µg of protein G-purified IgG in 200 µl PBS containing 0.2% gelatin and 0.05% sodium azide |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
|
| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
human SIRT7 amino acids 35-51 and 361-377
·
Host:
rabbit
·
Application(s):
WB
·
SIRT7 is a member of a famiy of proteins called sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast, and mammalian sirtuins are able to metabolize NAD+ and several act as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD+ metabolism and NAD+-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD+ and the N-e-acetyl-lysine groups of acetylated histone.
