| References |
| Formulation |
100 µg of protein G-purified IgG in 200 µl PBS containing 0.2% gelatin and 0.05% sodium azide |
| Stability |
6 months |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
| Human SMAD4 |
(+) |
| New World monkey SMAD4 |
(+) |
| Murine SMAD4 |
(+) |
| Rat SMAD4 |
(+) |
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|
| Size |
Global Purchasing |
| 100 µg |
|
Description
Antigen:
synthetic peptides corresponding to amino acids 186-199 and 509-523 of human SMAD4
·
Host:
rabbit
·
Application(s):
WB
·
Peptide sequence:
(PSNRASTETYSTPA) and (PSNRASTETYSTPA)
·
SMADs are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor β superfamily.1 SMADs can be divided into receptor-regulated SMADs (R-SMADs: SMAD1, SMAD2, SMAD3, SMAD5, SMAD8, and SMAD9), common-mediator SMAD (co-SMAD: SMAD4), and inhibitory SMADs (I-SMADs: SMAD6 and SMAD7). SMAD1, SMAD5, SMAD8, and SMAD9 have high degrees of homology and antibodies are available that recognize sequences common to all of them. SMAD8 and SMAD9 are typically used as alternate names for one another in the literature.
1
Topper, J.N., Cai, J., and Qui, Y. Vascular MADs: Two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc Natl Acad Sci USA 94 9314-9 (1997).
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