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021-60498804
| Cat. Number | 068995410014970 |
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| Chemical Name | Soluble Epoxide Hydrolase (FL) Polyclonal Antibody |
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| References |
Background ReadingSchmelzer, K.R., Kubala, L., Newman, J.W., et al. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc Natl Acad Sci USA 102(28) 9772-9777 (2005). Halarnkar, P.P., Wixtrom, R.N., Silva, M.H., et al. Catabolism of epoxy fatty esters by the purified epoxide hydrolase from mouse and human liver. Arch Biochem Biophys 272 226-236 (1989). Yu, Z., Xu, F., Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 87 992-998 (2000). Imig, J.D., Zhao, X., Zaharis, C.Z., et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-
Description
Antigen:
murine recombinant soluble epoxide hydrolase
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Host:
rabbit
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Application(s):
WB
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The metabolism of exogenous and endogenous epoxides relies in part upon the activity of soluble epoxide hydrolase (sEH).1 The relevance of sEH to hypertension and inflammation makes it a potentially useful clinical drug target. Specifically, the conversion of epoxyeicosatrienoic acids (EpETrEs; EETs) by sEH to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs; DHETs) diminishes their vasodilator activity.2 Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation.3,4 Cayman’s sEH polyclonal antibody is useful for monitoring the quantity and distribution of sEH.
1 Halarnkar, P.P., Wixtrom, R.N., Silva, M.H., et al. Catabolism of epoxy fatty esters by the purified epoxide hydrolase from mouse and human liver. Arch Biochem Biophys 272 226-236 (1989). 2 Yu, Z., Xu, F., Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 87 992-998 (2000).
3
Imig, J.D., Zhao, X., Zaharis, C.Z., et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt- 4 Schmelzer, K.R., Kubala, L., Newman, J.W., et al. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc Natl Acad Sci USA 102(28) 9772-9777 (2005). |
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