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Cat. Number
068973495003076
Chemical Name
sPLA2 (human Type IIA) Monoclonal Antibody (Clone SCACC353)
References
Synonyms
  • Secretory Phospholipase A2 (human synovial)
Formulation 500 µg of IgG, lyophilized
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Dennis, E.A. Phospholipases. Enzymes XVI 307-353 (1983).

Hulthe, J., Wiklund, O., Hurt-Camejo, E., et al. Antibodies to oxidized LDL in relation to carotid atherosclerosis, cell adhesion molecules, and phospholipase A2. Arterioscler Thromb Vasc Biol 21 269-274 (2001).

Peilot, H., Rosengren, B., Bondjers, G., et al. Interferon-γ induces secretory group IIA phospholipase A2 in human arterial smooth muscle cells. Involvement of cell differentiation, stat-3 activation, and modulation by other cytokines . J Biol Chem 275 (30) 22895-22904 (2000).

Dennis, E.A. Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem 269 13057-13060 (1994).

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1 ea  

Description

Antigen: recombinant human sPLA2 Type IIA · Clone designation: SCACC353 · Host: mouse · Isotype: IgG1 · Application(s): WB and IP; other applications not tested · Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position yielding a free fatty acid and a lysophospholipid.1 The release of arachidonic acid from membrane phospholipids by PLA2 is believed to be a key step in the control of eicosanoid production within the cell.2 Human synovial sPLA2 is a secreted, 14 kDa protein which is dependent on Ca2+ for optimal activity. Human synovial sPLA2 is 79% homologous to rat platelet and mouse type II sPLA2s.

1 Dennis, E.A. Phospholipases. Enzymes XVI 307-353 (1983).

2 Dennis, E.A. Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem 269 13057-13060 (1994).

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