Antigen:
synthetic peptide sequence corresponding to amino acids 711-730 of human STAT1
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Host:
rabbit
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Application(s):
WB
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Peptide sequence:
EVHPSRLQTTDNLLPMSPEE
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Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors.1 STAT1 is involved in the TNFR1-TRADD signaling complex.2 In Hela cells, STAT1 acts as a TNFR1-signaling molecule to suppress NF-κB activation. It has also been shown that its activation slows growth and promotes apoptosis.3
1
Stephens, J.M., Lumpkin, S.J., and Fishman, J.B. Activation of signal transducers and activators of transcription 1 and 3 by leukemia inhibitory factor, oncostatin-M, and interferon-γ in adipocytes. J Biol Chem 273 31408-31416 (1998).
2
Wang, Y., Wu, T.R., Cai, S., et al. Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling comples to inhibit NF-κB activation. Mol Cell Biol 20(13) 4505-12 (2000).
3
Anastasis, S., Brar, B.K., Scarabelli, T.M., et al. Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis. J Biol Chem 275(14) 10002-8 (2000).
