Antigen:
synthetic peptide corresponding to amino acids 830-849 of human STAT2
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Host:
rabbit
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Application(s):
WB
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Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors.1,2,3 After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5α, STAT5β, and STAT6), STAT1, STAT3, STAT5α, and STAT5β have a wide activation profile. Human STAT2 cDNA codes for a 851 amino acid protein with a predicted molecular weight of 113 kDa.4 STAT2 associates with β subunit of the type I IFN receptor in an interferon-dependent manner.5
1
Leonard, W.J., and O'Shea, J.J. JAKS AND STATS: Biological implications. Annu Rev Immunol 16 293-322 (1998).
2
Schindler, C., and Darnell, J.E. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway. Annu Rev Biochem 64 621-562 (2011).
3
Darnell, J.E. STATs and gene regulation. Science 277 1630-1635 (1997).
4
Bluyssen, H.A.R., and Levy, D.E. Stat2 is a transcriptional activator that requires sequence-specific contacts provided by Stat1 and p48 for stable interaction with DNA. J Biol Chem 272(7) 4600-5 (1997).
5
Uddin, S., Chamdin, A., and Platanias, L.C. Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. J Biol Chem 270(42) 24627-24630 (1995).
