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| Cat. Number | 068913232932164 |
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| Chemical Name | STAT3 (Phospho-Tyr705) Polyclonal Antibody |
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| References |
Description
Antigen:
portion of human STAT3 protein containing a phosphorylated tyrosine residue at position 705
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Host:
rabbit
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Application(s):
WB
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The Signal Transducers and Activators of Transcription (STAT) family is a group of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors.1,2 After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5α, STAT5β, and STAT6), STAT1, STAT3, STAT5α, and STAT5β have a wide activation profile.1,2 STAT1 and STAT3 can be activated simultaneously by the interactions of cells with the same polypeptide ligand. STAT3 is a transcription factor that binds to the interleukin-
1 Bates, S.H., Stearns, W.H., Dundon, T.A., et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421(6925) 856-9 (2003). 2 Bhattacharya, S., and Schindler, C. Regulation of Stat3 nuclear export. J Clin Invest 111(4) 553-9 (2003). |
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